Reduced Efficacy of Praziquantel AgainstSchistosoma mansoniIs Associated With Multiple Rounds of Mass Drug Administration | Zendy

Thomas Crellen | Zendy; Martin Walker | Zendy; Poppy H. L. Lamberton | Zendy; Narcis B. Kabatereine | Zendy; Edridah M. Tukahebwa | Zendy; James A. Cotton | Zendy; Joanne P. Webster | Zendy

Open Access

Reduced Efficacy of Praziquantel AgainstSchistosoma mansoniIs Associated With Multiple Rounds of Mass Drug Administration

Author(s) -

Thomas Crellen,

Martin Walker,

Poppy H. L. Lamberton,

Narcis B. Kabatereine,

Edridah M. Tukahebwa,

James A. Cotton,

Joanne P. Webster

Publication year - 2016

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciw506

Subject(s) - praziquantel , schistosoma mansoni , medicine , mass drug administration , schistosomiasis , schistosoma , credible interval , anthelmintic , helminthiasis , confidence interval , immunology , environmental health , helminths , veterinary medicine , population

Mass drug administration (MDA) with praziquantel is the cornerstone of schistosomiasis control in sub-Saharan Africa. The effectiveness of this strategy is dependent on the continued high efficacy of praziquantel; however, drug efficacy is rarely monitored using appropriate statistical approaches that can detect early signs of wane.

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