Human Leukocyte Antigen-G: A Promising Prognostic Marker of Disease Progression to Improve the Control of Human African Trypanosomiasis | Zendy

Laure Gineau | Zendy; David Courtin | Zendy; Mamadou Camara | Zendy; Hamidou Ilboudo | Zendy; Vincent Jamonneau | Zendy; Fabrício C. Dias | Zendy; Léonidas Tokplonou | Zendy; Jacqueline Milet | Zendy; Priscila Baptista Mendonça | Zendy; Erick C. Castelli | Zendy; Oumou Camara | Zendy; Mariam Camara | Zendy; Benoı̂t Favier | Zendy; Nathalie RouasFreiss | Zendy; Philippe Moreau | Zendy; Eduardo Antônio Donadi | Zendy; Bruno Bucheton | Zendy; Audrey Sabbagh | Zendy; André Garcia | Zendy

Open Access

Human Leukocyte Antigen-G: A Promising Prognostic Marker of Disease Progression to Improve the Control of Human African Trypanosomiasis

Author(s) -

Laure Gineau,

David Courtin,

Mamadou Camara,

Hamidou Ilboudo,

Vincent Jamonneau,

Fabrício C. Dias,

Léonidas Tokplonou,

Jacqueline Milet,

Priscila Baptista Mendonça,

Erick C. Castelli,

Oumou Camara,

Mariam Camara,

Benoı̂t Favier,

Nathalie RouasFreiss,

Philippe Moreau,

Eduardo Antônio Donadi,

Bruno Bucheton,

Audrey Sabbagh,

André Garcia

Publication year - 2016

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciw505

Subject(s) - african trypanosomiasis , human leukocyte antigen , antigen , medicine , immunology , serology , hla g , stage (stratigraphy) , trypanosomiasis , disease , antibody , trypanosoma brucei , parasitology , biology , pathology , genetics , gene , paleontology

Human African trypanosomiasis (HAT) caused by Trypanosoma brucei gambiense can be diagnosed in the early hemolymphatic stage (stage 1 [S1]) or meningoencephalitic stage (stage 2 [S2]). Importantly, individuals harbouring high and specific antibody responses to Tbg antigens but negative parasitology are also diagnosed in the field (seropositive [SERO]). Whereas some develop the disease in the months following their initial diagnosis (SERO/HAT), others remain parasitologically negative for long periods (SERO) and are apparently able to control infection. Human leucocyte antigen (HLA)-G, an immunosuppressive molecule, could play a critical role in this variability of progression between infection and disease.

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