Open AccessBaseline Predictors of Treatment Outcomes in Children With Multidrug-Resistant Tuberculosis: A Retrospective Cohort Study
Author(s) -
Silvia S. Chiang,
Jeffrey R. Starke,
Ann C. Miller,
Andrea T. Cruz,
Hernán Del Castillo,
William José Valdivia,
Gabriela Tunque,
Fanny García,
Carmen Contreras,
Leonid Lecca,
Valentina A. Alarcón,
Mercedes C. Becerra
Publication year - 2016
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciw489
Subject(s) - medicine , tuberculosis , retrospective cohort study , odds ratio , extensively drug resistant tuberculosis , pediatrics , cohort study , surgery , mycobacterium tuberculosis , pathology
Globally, >30 000 children fall sick with multidrug-resistant (MDR) tuberculosis every year. Without robust pediatric data, clinical management follows international guidelines that are based on studies in adults and expert opinion. We aimed to identify baseline predictors of death, treatment failure, and loss to follow-up among children with MDR tuberculosis disease treated with regimens tailored to their drug susceptibility test (DST) result or to the DST result of a source case.
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