Cough Aerosols ofMycobacterium tuberculosisin the Prediction of Incident Tuberculosis Disease in Household Contacts | Zendy

Edward C. JonesLópez | Zendy; Carlos Acuña-Villaorduña | Zendy; Martin Ssebidandi | Zendy; Mary Gaeddert | Zendy; Rachel W. Kubiak | Zendy; Irene Ayakaka | Zendy; Laura F. White | Zendy; Moses Joloba | Zendy; Alphonse Okwera | Zendy; Kevin P. Fennelly | Zendy

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Cough Aerosols ofMycobacterium tuberculosisin the Prediction of Incident Tuberculosis Disease in Household Contacts

Author(s) -

Edward C. JonesLópez,

Carlos Acuña-Villaorduña,

Martin Ssebidandi,

Mary Gaeddert,

Rachel W. Kubiak,

Irene Ayakaka,

Laura F. White,

Moses Joloba,

Alphonse Okwera,

Kevin P. Fennelly

Publication year - 2016

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciw199

Subject(s) - tuberculosis , medicine , sputum , mycobacterium tuberculosis , odds ratio , disease , immunology , pathology

Tuberculosis disease develops in only 5%-10% of humans infected with Mycobacterium tuberculosis The mechanisms underlying this variability remain poorly understood. We recently demonstrated that colony-forming units of M. tuberculosis in cough-generated aerosols are a better predictor of infection than the standard sputum acid-fast bacilli smear. We hypothesized that cough aerosol cultures may also predict progression to tuberculosis disease in contacts.

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