A Phase 3, Double-Blind, Randomized Study of Arterolane Maleate–Piperaquine Phosphate vs Artemether–Lumefantrine for Falciparum Malaria in Adolescent and Adult Patients in Asia and Africa | Zendy

Offianan André Touré | Zendy; Neena Valecha | Zendy; Antoinette Tshefu | Zendy; Ricardo Thompson | Zendy; Srivicha Krudsood | Zendy; Oumar Gaye | Zendy; Bappanaidu Hoigegudde Krishnamurthy Rao | Zendy; Issaka Sagara | Zendy; Tarit K. Bose | Zendy; Sanjib Mohanty | Zendy; Ballamudi Srinivas Rao | Zendy; Anupkumar R. Anvikar | Zendy; Victor Mwapasa | Zendy; Harald Noedl | Zendy; Sudershan K. Arora | Zendy; Arjun Roy | Zendy; Sunil S. Iyer | Zendy; Pradeep Sharma | Zendy; Nilanjan Saha | Zendy; Rajinder K. Jalali | Zendy

Open Access

A Phase 3, Double-Blind, Randomized Study of Arterolane Maleate–Piperaquine Phosphate vs Artemether–Lumefantrine for Falciparum Malaria in Adolescent and Adult Patients in Asia and Africa

Author(s) -

Offianan André Touré,

Neena Valecha,

Antoinette Tshefu,

Ricardo Thompson,

Srivicha Krudsood,

Oumar Gaye,

Bappanaidu Hoigegudde Krishnamurthy Rao,

Issaka Sagara,

Tarit K. Bose,

Sanjib Mohanty,

Ballamudi Srinivas Rao,

Anupkumar R. Anvikar,

Victor Mwapasa,

Harald Noedl,

Sudershan K. Arora,

Arjun Roy,

Sunil S. Iyer,

Pradeep Sharma,

Nilanjan Saha,

Rajinder K. Jalali

Publication year - 2016

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciw029

Subject(s) - medicine , artemether/lumefantrine , incidence (geometry) , lumefantrine , piperaquine , adverse effect , gastroenterology , malaria , artemether , randomized controlled trial , surgery , artemisinin , plasmodium falciparum , immunology , physics , optics

Artemisinins, which are derived from plants, are subject to risk of supply interruption due to climatic changes. Consequently, an effort to identify a new synthetic antimalarial was initiated. A fixed-dose combination of arterolane maleate (AM), a new synthetic trioxolane, with piperaquine phosphate (PQP), a long half-life bisquinoline, was evaluated in patients with uncomplicatedPlasmodium falciparummalaria.

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