Virus and Host Testing to Manage Chronic Hepatitis B | Zendy

Grace LaiHung Wong | Zendy; Vincent WaiSun Wong | Zendy; Henry LikYuen Chan | Zendy

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Virus and Host Testing to Manage Chronic Hepatitis B

Author(s) -

Grace LaiHung Wong,

Vincent WaiSun Wong,

Henry LikYuen Chan

Publication year - 2016

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciw024

Subject(s) - medicine , hepatitis b virus , hepatocellular carcinoma , virology , natural history , cirrhosis , virus , immunology , serology , chronic infection , chronic hepatitis , hepatitis b , liver disease , immune system , antibody

Chronic hepatitis B virus (HBV) infection is a major cause of cirrhosis and hepatocellular carcinoma worldwide. The past 50 years have seen rapid developments in HBV testing. Beginning from traditional serologic tests, the availability of sensitive HBV DNA assays allows a thorough understanding of the virology and natural history of chronic HBV infection. Quantification of hepatitis B surface antigen levels reflects the amount and transcriptional activities of covalently closed circular DNA in the liver and may be used to evaluate the stage of disease and guide antiviral therapy. The natural history of chronic HBV infection is also a manifestation of the interaction between the host and the virus, and recent genomic works have shed light on the host-virus relationship and may provide novel tests in the future. This review highlights recent advances in the application of HBV tests in the management of chronic hepatitis B.

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