Severe Paradoxical Reaction During Treatment of Disseminated Tuberculosis in a Patient With Neutralizing Anti-IFNγ Autoantibodies | Zendy

Yingda L. Xie | Zendy; Lindsey B. Rosen | Zendy; Irini Sereti | Zendy; Daniel L. Barber | Zendy; Ray Y. Chen | Zendy; Denise C. Hsu | Zendy; Sarojini S. Qasba | Zendy; Christa S. Zerbe | Zendy; Steven M. Holland | Zendy; Sarah K. Browne | Zendy

Open Access

Severe Paradoxical Reaction During Treatment of Disseminated Tuberculosis in a Patient With Neutralizing Anti-IFNγ Autoantibodies

Author(s) -

Yingda L. Xie,

Lindsey B. Rosen,

Irini Sereti,

Daniel L. Barber,

Ray Y. Chen,

Denise C. Hsu,

Sarojini S. Qasba,

Christa S. Zerbe,

Steven M. Holland,

Sarah K. Browne

Publication year - 2015

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/civ995

Subject(s) - tuberculosis , medicine , autoantibody , immunology , titer , paradoxical reaction , interferon γ , mycobacterium tuberculosis , interferon gamma , antibody , pathology , cytokine

Interferon-gamma (IFNγ) neutralizing autoantibodies are associated with disseminated nontuberculous mycobacterial infections. We report a previously healthy Thai woman with disseminated tuberculosis and high-titer IFNγ-neutralizing autoantibodies, who developed a severe inflammatory reaction during anti-tuberculosis treatment. IFNγ contributes to host control of tuberculosis but appears inessential for tuberculosis paradoxical reactions.

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