Robust Reconstitution of Tuberculosis-Specific Polyfunctional CD4+T-Cell Responses and Rising Systemic Interleukin 6 in Paradoxical Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome | Zendy

Shruthi Ravimohan | Zendy; Neo Tamuhla | Zendy; Kebatshabile Nfanyana | Zendy; Andrew P. Steenhoff | Zendy; Rona Letlhogile | Zendy; Ian Frank | Zendy; Rob Roy MacGregor | Zendy; Robert Gross | Zendy; Drew Weissman | Zendy; Gregory P. Bisson | Zendy

Open Access

Robust Reconstitution of Tuberculosis-Specific Polyfunctional CD4⁺T-Cell Responses and Rising Systemic Interleukin 6 in Paradoxical Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome

Author(s) -

Shruthi Ravimohan,

Neo Tamuhla,

Kebatshabile Nfanyana,

Andrew P. Steenhoff,

Rona Letlhogile,

Ian Frank,

Rob Roy MacGregor,

Robert Gross,

Drew Weissman,

Gregory P. Bisson

Publication year - 2015

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/civ978

Subject(s) - immune reconstitution inflammatory syndrome , medicine , immunology , tuberculosis , immune system , t cell , tumor necrosis factor alpha , latent tuberculosis , mycobacterium tuberculosis , viral load , virus , pathology , antiretroviral therapy

The immunopathogenesis of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) remains unclear. We determined the association between pathogen-specific T-cell responses and development of paradoxical TB-IRIS on antiretroviral therapy (ART).

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