Lovastatin for the Treatment of Adult Patients With Dengue: A Randomized, Double-Blind, Placebo-Controlled Trial | Zendy

James Whitehorn | Zendy; Nguyễn Văn Vĩnh Châu | Zendy; Phung Khanh Lam | Zendy; Duong Thi Hue Kien | Zendy; Nguyen Than Ha Quyen | Zendy; Nguyen Thi Thanh Tran | Zendy; Nguyen Thuy Hang | Zendy; Nguyen Thanh Truong | Zendy; Luong Thi Hue Tai | Zendy; Nguyen Thi Cam Huong | Zendy; Vo Thanh Nhon | Zendy; Ta Van Tram | Zendy; Jeremy Farrar | Zendy; Marcel Wolbers | Zendy; Cameron P. Simmons | Zendy; Bridget Wills | Zendy

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Lovastatin for the Treatment of Adult Patients With Dengue: A Randomized, Double-Blind, Placebo-Controlled Trial

Author(s) -

James Whitehorn,

Nguyễn Văn Vĩnh Châu,

Phung Khanh Lam,

Duong Thi Hue Kien,

Nguyen Than Ha Quyen,

Nguyen Thi Thanh Tran,

Nguyen Thuy Hang,

Nguyen Thanh Truong,

Luong Thi Hue Tai,

Nguyen Thi Cam Huong,

Vo Thanh Nhon,

Ta Van Tram,

Jeremy Farrar,

Marcel Wolbers,

Cameron P. Simmons,

Bridget Wills

Publication year - 2015

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/civ949

Subject(s) - medicine , dengue fever , lovastatin , placebo , adverse effect , statin , clinical trial , randomized controlled trial , viremia , surgery , immunology , cholesterol , pathology , virus , alternative medicine

Dengue endangers billions of people in the tropical world, yet no therapeutic is currently available. In part, the severe manifestations of dengue reflect inflammatory processes affecting the vascular endothelium. In addition to lipid lowering, statins have pleiotropic effects that improve endothelial function, and epidemiological studies suggest that outcomes from a range of acute inflammatory syndromes are improved in patients already on statin therapy.

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