Host Genetic Susceptibility to Enteric Viruses: A Systematic Review and Metaanalysis | Zendy

Anita Kambhampati | Zendy; Daniel C. Payne | Zendy; Verónica Costantini | Zendy; Benjamin A. Lopman | Zendy

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Host Genetic Susceptibility to Enteric Viruses: A Systematic Review and Metaanalysis

Author(s) -

Anita Kambhampati,

Daniel C. Payne,

Verónica Costantini,

Benjamin A. Lopman

Publication year - 2015

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/civ873

Subject(s) - medicine , virology , enteric virus , host (biology) , enteric fever , microbiology and biotechnology , genetics , biology , typhoid fever

Norovirus and rotavirus are prominent enteric viruses responsible for severe acute gastroenteritis disease burden around the world. Both viruses recognize and bind to histo-blood group antigens, which are expressed by the fucosyltransferase 2 (FUT2) gene. Individuals with a functional FUT2 gene are termed "secretors." FUT2 polymorphisms may influence viral binding patterns and, therefore, may influence host susceptibility to infection by these viruses.

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