Early, Real-Time Medical Diagnosis of Botulism by Endopeptidase-Mass Spectrometry | Zendy

Osnat Rosen | Zendy; Liron Feldberg | Zendy; Sigalit Gura | Zendy; Tal BroshNissimov | Zendy; Alex Guri | Zendy; Oren Zimhony | Zendy; Eli Shapiro | Zendy; Adi Beth-Din | Zendy; Dana Stein | Zendy; Eyal Ozeri | Zendy; Ada Barnea | Zendy; Amram Turgeman | Zendy; Alon Ben David | Zendy; Arieh Schwartz | Zendy; Eytan Elhanany | Zendy; Eran Diamant | Zendy; Shmuel Yitzhaki | Zendy; Ran Zichel | Zendy

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Early, Real-Time Medical Diagnosis of Botulism by Endopeptidase-Mass Spectrometry

Author(s) -

Osnat Rosen,

Liron Feldberg,

Sigalit Gura,

Tal BroshNissimov,

Alex Guri,

Oren Zimhony,

Eli Shapiro,

Adi Beth-Din,

Dana Stein,

Eyal Ozeri,

Ada Barnea,

Amram Turgeman,

Alon Ben David,

Arieh Schwartz,

Eytan Elhanany,

Eran Diamant,

Shmuel Yitzhaki,

Ran Zichel

Publication year - 2015

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/civ861

Subject(s) - botulism , medicine , endopeptidase , antitoxin , mass spectrometry , clostridium botulinum , microbiology and biotechnology , toxin , chromatography , enzyme , biology , chemistry , biochemistry

Botulinum toxin was detected in patient serum using Endopeptidase-mass-spectrometry assay, although all conventional tests provided negative results. Antitoxin was administered, resulting in patient improvement. Implementing this highly sensitive and rapid assay will improve preparedness for foodborne botulism and deliberate exposure.

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