CD8 T-Cell Expansion and Inflammation Linked to CMV Coinfection in ART-treated HIV Infection | Zendy

Michael L. Freeman | Zendy; Joseph C. Mudd | Zendy; Carey L. Shive | Zendy; Souheil-Antoine Younes | Zendy; Soumya Panigrahi | Zendy; Scott F. Sieg | Zendy; Sulggi A. Lee | Zendy; Peter W. Hunt | Zendy; Leonard H. Calabrese | Zendy; Sara Gianella | Zendy; Benigno Rodríguez | Zendy; Michael M. Lederman | Zendy

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CD8 T-Cell Expansion and Inflammation Linked to CMV Coinfection in ART-treated HIV Infection

Author(s) -

Michael L. Freeman,

Joseph C. Mudd,

Carey L. Shive,

Souheil-Antoine Younes,

Soumya Panigrahi,

Scott F. Sieg,

Sulggi A. Lee,

Peter W. Hunt,

Leonard H. Calabrese,

Sara Gianella,

Benigno Rodríguez,

Michael M. Lederman

Publication year - 2015

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/civ840

Subject(s) - medicine , coinfection , cd8 , immunology , cytomegalovirus , cd4 cd8 ratio , systemic inflammation , human cytomegalovirus , inflammation , viral load , human immunodeficiency virus (hiv) , virus , viral disease , immune system , herpesviridae , lymphocyte subsets

Persistent CD8 T-cell expansion, low CD4/CD8 T-cell ratios, and heightened inflammation persist in antiretroviral therapy (ART)-treated human immunodeficiency virus (HIV) infection and are associated with increased risk of morbid outcomes. We explored the role of cytomegalovirus (CMV) infection in CD8 lymphocytosis and inflammation in ART-treated HIV infection.

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