Association of Single-Nucleotide Polymorphisms inIL28B,but NotTNF-α,With Severity of Disease Caused by Andes Virus | Zendy

Jenniffer Angulo | Zendy; Karla Pino | Zendy; Natalia Echeverría | Zendy; Claudia Marco | Zendy; Constanza Martínez-Valdebenito | Zendy; H. Galeno | Zendy; Eliecer Villagra | Zendy; Lilian Vera | Zendy; Natalia Lagos | Zendy; Natalia Becerra | Zendy; Judith Mora | Zendy; Andrea K. Hurtado Bermúdez | Zendy; Marcela Cárcamo | Zendy; Janepsy Díaz | Zendy; Juan Francisco Miquel | Zendy; Marcela Ferrés | Zendy; Marcelo LópezLastra | Zendy

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Association of Single-Nucleotide Polymorphisms inIL28B,but NotTNF-α,With Severity of Disease Caused by Andes Virus

Author(s) -

Jenniffer Angulo,

Karla Pino,

Natalia Echeverría,

Claudia Marco,

Constanza Martínez-Valdebenito,

H. Galeno,

Eliecer Villagra,

Lilian Vera,

Natalia Lagos,

Natalia Becerra,

Judith Mora,

Andrea K. Hurtado Bermúdez,

Marcela Cárcamo,

Janepsy Díaz,

Juan Francisco Miquel,

Marcela Ferrés,

Marcelo LópezLastra

Publication year - 2015

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/civ830

Subject(s) - single nucleotide polymorphism , snp , minor allele frequency , allele , genetic association , genotype , medicine , biology , immunology , genetics , virology , gene

Andes virus (ANDV) is the sole etiologic agent of hantavirus cardiopulmonary syndrome (HCPS) in Chile, with a fatality rate of about 35%. Individual host factors affecting ANDV infection outcome are poorly understood. In this case-control genetic association analysis, we explored the link between single-nucleotide polymorphisms (SNPs) rs12979860, rs8099917 and rs1800629 and the clinical outcome of ANDV-induced disease. The SNPs rs12979860 and rs8099917 are known to play a role in the differential expression of the interleukin 28B gene (IL28B), whereas SNP rs1800629 is implicated in the expression of tumor necrosis factor α gene (TNF-α).

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