Prevaccination Rotavirus Serum IgG and IgA Are Associated With Lower Immunogenicity of Live, Oral Human Rotavirus Vaccine in South African Infants | Zendy

Sung-Sil Moon | Zendy; Michelle J. Groome | Zendy; Daniel E. Velásquez | Zendy; Umesh D. Parashar | Zendy; Stephanie Jones | Zendy; Antoinette Koen | Zendy; Nadia van Niekerk | Zendy; Baoming Jiang | Zendy; Shabir A. Madhi | Zendy

Open Access

Prevaccination Rotavirus Serum IgG and IgA Are Associated With Lower Immunogenicity of Live, Oral Human Rotavirus Vaccine in South African Infants

Author(s) -

Sung-Sil Moon,

Michelle J. Groome,

Daniel E. Velásquez,

Umesh D. Parashar,

Stephanie Jones,

Antoinette Koen,

Nadia van Niekerk,

Baoming Jiang,

Shabir A. Madhi

Publication year - 2015

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/civ828

Subject(s) - immunogenicity , medicine , rotavirus vaccine , rotavirus , immunology , immunoglobulin a , virology , reoviridae , immunoglobulin g , vaccination , antibody , virus

Live oral rotavirus (RV) vaccines have shown modest efficacy among children in African countries for reasons that are not completely understood. We examined the possible inhibitory effect of preexisting antirotavirus antibodies on immunogenicity of monovalent RV vaccine (RV1).

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