Early Initiation Rather Than Prolonged Duration of Antiretroviral Therapy in HIV Infection Contributes to the Normalization of CD8 T-Cell Counts | Zendy

Wei Cao | Zendy; Vikram Mehraj | Zendy; Benoît Trottier | Zendy; Jean-Guy Baril | Zendy; Roger LeBlanc | Zendy; Bertrand Lebouché | Zendy; Joseph Cox | Zendy; Cécile Tremblay | Zendy; Wei Lu | Zendy; Joel Singer | Zendy; Taisheng Li | Zendy; JeanPierre Routy | Zendy

Open Access

Early Initiation Rather Than Prolonged Duration of Antiretroviral Therapy in HIV Infection Contributes to the Normalization of CD8 T-Cell Counts

Author(s) -

Wei Cao,

Vikram Mehraj,

Benoît Trottier,

Jean-Guy Baril,

Roger LeBlanc,

Bertrand Lebouché,

Joseph Cox,

Cécile Tremblay,

Wei Lu,

Joel Singer,

Taisheng Li,

JeanPierre Routy

Publication year - 2015

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/civ809

Subject(s) - medicine , cd8 , viral load , antiretroviral therapy , chronic infection , immunology , cd4 cd8 ratio , human immunodeficiency virus (hiv) , gastroenterology , immune system , lymphocyte subsets

CD8 T-cell counts remain elevated in human immunodeficiency virus (HIV) infection even after long-term antiretroviral therapy (ART), which is associated with an increased risk of non-AIDS-related events. We assessed the impact of ART initiation in early versus chronic HIV infection on trajectories of CD8 cell counts over time.

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