Mathematical Modeling to Assess the Drivers of the Recent Emergence of Typhoid Fever in Blantyre, Malawi | Zendy

Virginia E. Pitzer | Zendy; Nicholas Feasey | Zendy; Chisomo Msefula | Zendy; Jane Mallewa | Zendy; Neil Kennedy | Zendy; Queen Dube | Zendy; Brigitte Denis | Zendy; Melita A. Gordon | Zendy; Robert S. Heyderman | Zendy

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Mathematical Modeling to Assess the Drivers of the Recent Emergence of Typhoid Fever in Blantyre, Malawi

Author(s) -

Virginia E. Pitzer,

Nicholas Feasey,

Chisomo Msefula,

Jane Mallewa,

Neil Kennedy,

Queen Dube,

Brigitte Denis,

Melita A. Gordon,

Robert S. Heyderman

Publication year - 2015

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/civ710

Subject(s) - typhoid fever , salmonella typhi , transmission (telecommunications) , biology , salmonella , population , outbreak , virology , salmonella enterica , demography , genetics , escherichia coli , sociology , bacteria , electrical engineering , gene , engineering

Multiyear epidemics of Salmonella enterica serovar Typhi have been reported from countries across eastern and southern Africa in recent years. In Blantyre, Malawi, a dramatic increase in typhoid fever cases has recently occurred, and may be linked to the emergence of the H58 haplotype. Strains belonging to the H58 haplotype often exhibit multidrug resistance and may have a fitness advantage relative to other Salmonella Typhi strains.

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