Role ofCoccidioidesAntigen Testing in the Cerebrospinal Fluid for the Diagnosis of Coccidioidal Meningitis | Zendy

Christelle Kassis | Zendy; Syed Sohail Zahoor Zaidi | Zendy; T. Kuberski | Zendy; Ana Moran | Zendy; Omar Gonzalez | Zendy; Sana Hussain | Zendy; Carlos Hartmann-Manrique | Zendy; Layth Al-Jashaami | Zendy; Ahmad Chebbo | Zendy; Robert A. Myers | Zendy; L. Joseph Wheat | Zendy

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Role ofCoccidioidesAntigen Testing in the Cerebrospinal Fluid for the Diagnosis of Coccidioidal Meningitis

Author(s) -

Christelle Kassis,

Syed Sohail Zahoor Zaidi,

T. Kuberski,

Ana Moran,

Omar Gonzalez,

Sana Hussain,

Carlos Hartmann-Manrique,

Layth Al-Jashaami,

Ahmad Chebbo,

Robert A. Myers,

L. Joseph Wheat

Publication year - 2015

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/civ585

Subject(s) - coccidioides , medicine , cerebrospinal fluid , meningitis , complement fixation test , antibody , coccidioides immitis , antigen , immunoassay , immunology , pathology , immunodiffusion , serology , dermatology , surgery

Coccidioidal meningitis (CM), a common cause of chronic meningitis in endemic area, is usually diagnosed by detection of anti-Coccidioides antibodies in cerebrospinal fluid (CSF), and findings may be negative in up to one-third of cases. CSF cultures and cytology are infrequently positive. Antigen detection has been used for the diagnosis of other forms of coccidioidomycosis and meningitis caused by other mycoses. The purpose of this study was to assess the diagnostic utility of CSF Coccidioides antigen (CAg) detection for the diagnosis of CM.

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