The Distribution of Fitness Costs of Resistance-Conferring Mutations Is a Key Determinant for the Future Burden of Drug-Resistant Tuberculosis: A Model-Based Analysis | Zendy

Gwenan M. Knight | Zendy; Caroline Colijn | Zendy; Sourya Shrestha | Zendy; Mariam O. Fofana | Zendy; Frank Cobelens | Zendy; Richard G. White | Zendy; David W. Dowdy | Zendy; Ted Cohen | Zendy

Open Access

The Distribution of Fitness Costs of Resistance-Conferring Mutations Is a Key Determinant for the Future Burden of Drug-Resistant Tuberculosis: A Model-Based Analysis

Author(s) -

Gwenan M. Knight,

Caroline Colijn,

Sourya Shrestha,

Mariam O. Fofana,

Frank Cobelens,

Richard G. White,

David W. Dowdy,

Ted Cohen

Publication year - 2015

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/civ579

Subject(s) - drug resistance , tuberculosis , medicine , mycobacterium tuberculosis , genetic fitness , drug , transmission (telecommunications) , microbiology and biotechnology , biology , environmental health , genetics , population , computer science , pharmacology , telecommunications , pathology

Drug resistance poses a serious challenge for the control of tuberculosis in many settings. It is well established that the expected future trend in resistance depends on the reproductive fitness of drug-resistant Mycobacterium tuberculosis. However, the variability in fitness between strains with different resistance-conferring mutations has been largely ignored when making these predictions.

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