Discordant Syphilis Immunoassays in Pregnancy: Perinatal Outcomes and Implications for Clinical Management | Zendy

Okeoma Mmeje | Zendy; Joan M. Chow | Zendy; Lisette Davidson | Zendy; Jennifer Shieh | Zendy; Jeffrey M. Schapiro | Zendy; Ina U. Park | Zendy

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Discordant Syphilis Immunoassays in Pregnancy: Perinatal Outcomes and Implications for Clinical Management

Author(s) -

Okeoma Mmeje,

Joan M. Chow,

Lisette Davidson,

Jennifer Shieh,

Jeffrey M. Schapiro,

Ina U. Park

Publication year - 2015

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/civ445

Subject(s) - medicine , rapid plasma reagin , syphilis , serology , obstetrics , pregnancy , treponema , gynecology , immunology , antibody , human immunodeficiency virus (hiv) , biology , genetics

The reverse sequence algorithm is often used for prenatal syphilis screening by high-volume laboratories, beginning with a treponemal test such as the chemiluminescence immunoassay (CIA), followed by testing of CIA-positive (CIA(+)) specimens with the rapid plasma reagin test (RPR). The clinical significance of discordant serology (CIA(+)/RPR(-)) for maternal and neonatal outcomes is unknown.

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