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In clinical trials of interferon-free, direct-acting antiviral treatment of chronic hepatitis C, subjects who received ribavirin had reduced lymphocyte levels (median decline of approximately 0.4-0.5 × 10(9) cells/L). A modest decline in CD4(+) T cells was observed in subjects with human immunodeficiency virus type 1 coinfection without documented opportunistic infections.

clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)

Ribavirin Reduces Absolute Lymphocyte Counts in Hepatitis C Virus–Infected Patients Treated With Interferon-Free, Direct-Acting Antiviral Regimens: Figure 1.