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Practice guidelines for the management of bacterial meningitis. Clin Infect Dis 2004; 39:1267–84. 5. Abulhasan YB, Al-Jehani H, Valiquette MA, et al. Lumbar drainage for the treatment of severe bacterial meningitis. Neurocrit Care 2013; 19:199–205. 6. van de Beek D, de Gans J, Spanjaard L, Weisfelt M, Reitsma JB, Vermeulen M. Clinical features and prognostic factors in adults with bacterial meningitis. N Engl J Med 2004; 351:1849–59. 7. Glimaker M, Johansson B, Halldorsdottir H, et al. Neuro-intensive treatment targeting intracranial hypertension improves outcome in severe bacterial meningitis: an intervention-control study. PLoS One 2014; 9: e91976. 8. Gopal AK, Whitehouse JD, Simel DL, Corey GR. Cranial computed tomography before lumbar puncture: a prospective clinical evaluation. Arch Intern Med 1999; 159: 2681–5. 9. Hasbun R, Abrahams J, Jekel J, Quagliarello VJ. Computed tomography of the head before lumbar puncture in adults with suspected meningitis. N Engl J Med 2001; 345:1727–33. 10. Joffe AR. Lumbar puncture and brain herniation in acute bacterial meningitis: a review. J Intensive Care Med 2007; 22:194–207. 11. Majed B, Zephir H, Pichonnier-Cassagne V, et al. Lumbar punctures: use and diagnostic efficiency in emergency medical departments. Int J Emerg Med 2009; 2:227–35. 12. Chia D, Yavari Y, Kirsanov E, Aronin SI, Sadigh M. Adherence to standard of care in the diagnosis and treatment of suspected bacterial meningitis. Am J Med Qual 2014; doi:10.1177/1062860614545778. 13. Brouwer MC, Coutinho JM, van de Beek D. Clinical characteristics and outcome of brain abscess: systematic review and metaanalysis. Neurology 2014; 82:806–13. 14. Tattevin P, Bruneel F, Clair B, et al. Bacterial brain abscesses: a retrospective study of 94 patients admitted to an intensive care unit (1980 to 1999). Am J Med 2003; 115:143–6. 15. Koster-Rasmussen R, Korshin A, Meyer CN. Antibiotic treatment delay and outcome in acute bacterial meningitis. J Infect 2008; 57:449–54. 16. Proulx N, Fréchette D, Toye B, Chan J, Kravcik S. Delays in the administration of antibiotics are associated with mortality from adult acute bacterial meningitis. QJM 2005; 98:291–8.

Hepatitis C Virus RNA Levels During Interferon-Free Combination Direct-Acting Antiviral Treatment in Registrational Trials: Table 1.