The Return of Delayed-Type Hypersensitivity Skin Testing for Coccidioidomycosis | Zendy

Elizabeth E. Wack | Zendy; Neil M. Ampel | Zendy; Rebecca Sunenshine | Zendy; John N. Galgiani | Zendy

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The Return of Delayed-Type Hypersensitivity Skin Testing for Coccidioidomycosis

Author(s) -

Elizabeth E. Wack,

Neil M. Ampel,

Rebecca Sunenshine,

John N. Galgiani

Publication year - 2015

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/civ388

Subject(s) - medicine , coccidioides , skin test , dermatology , coccidioides immitis , epidemiology , test (biology) , delayed hypersensitivity , diagnostic test , immunology , intensive care medicine , antigen , pathology , pediatrics , tuberculosis , paleontology , biology

A skin test that detects dermal hypersensitivity in persons with past infection with Coccidioides species is again available for clinical use. Nearly all of the clinical studies with similar materials were published prior to the 1990s, and as a result, many practicing physicians will be unfamiliar with how skin testing for coccidioidomycosis might be useful in patient management or as a research tool. We review clinical and epidemiological studies with past skin test antigens, the composition of past and current skin test preparations with particular attention to differences in the preservatives, and how the current preparation could be used today.

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