Doxycycline Leads to Sterility and Enhanced Killing of FemaleOnchocerca volvulusWorms in an Area With Persistent Microfilaridermia After Repeated Ivermectin Treatment: A Randomized, Placebo-Controlled, Double-Blind Trial | Zendy

Alexander Yaw Debrah | Zendy; Sabine Specht | Zendy; Ute KlarmannSchulz | Zendy; Linda Batsa Debrah | Zendy; Sabine Mand | Zendy; Yeboah MarfoDebrekyei | Zendy; Rolf Fimmers | Zendy; Bettina Dubben | Zendy; Alexander Kwarteng | Zendy; Mike Y. OseiAtweneboana | Zendy; Daniel A. Boakye | Zendy; Arcangelo Ricchiuto | Zendy; Marcelle Büttner | Zendy; Ohene Adjei | Zendy; Charles D. Mackenzie | Zendy; Achim Hoerauf | Zendy

Open Access

Doxycycline Leads to Sterility and Enhanced Killing of FemaleOnchocerca volvulusWorms in an Area With Persistent Microfilaridermia After Repeated Ivermectin Treatment: A Randomized, Placebo-Controlled, Double-Blind Trial

Author(s) -

Alexander Yaw Debrah,

Sabine Specht,

Ute KlarmannSchulz,

Linda Batsa Debrah,

Sabine Mand,

Yeboah MarfoDebrekyei,

Rolf Fimmers,

Bettina Dubben,

Alexander Kwarteng,

Mike Y. OseiAtweneboana,

Daniel A. Boakye,

Arcangelo Ricchiuto,

Marcelle Büttner,

Ohene Adjei,

Charles D. Mackenzie,

Achim Hoerauf

Publication year - 2015

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/civ363

Subject(s) - doxycycline , onchocerca volvulus , onchocerciasis , ivermectin , medicine , wolbachia , placebo , antibiotics , randomized controlled trial , surgery , immunology , biology , pathology , veterinary medicine , microbiology and biotechnology , ecology , alternative medicine , host (biology)

Ivermectin (IVM) has been the drug of choice for the treatment of onchocerciasis. However, there have been reports of persistent microfilaridermia in individuals from an endemic area in Ghana after many rounds of IVM, raising concerns of suboptimal response or even the emergence of drug resistance. Because it is considered risky to continue relying only on IVM to combat this phenomenon, we assessed the effect of targeting the Onchocerca volvulus Wolbachia endosymbionts with doxycycline for these individuals with suboptimal response.

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