Effects of Emtricitabine/Tenofovir on Bone Mineral Density in HIV-Negative Persons in a Randomized, Double-Blind, Placebo-Controlled Trial
Author(s) -
Kathleen Mulligan,
David V. Glidden,
Peter L. Anderson,
Albert Liu,
Vanessa McMahan,
Pedro Gonzáles,
Maria Esther Ramirez-Cardich,
Siriag Namwongprom,
Piotr Chodacki,
Laura Maria Carvalo de Mendonca,
Furong Wang,
Javier R. Lama,
Suwat Chariyalertsak,
Juan V. Guanira,
Susan Buchbinder,
LindaGail Bekker,
Mauro Schechter,
Valdiléa G. Veloso,
Robert M. Grant
Publication year - 2015
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/civ324
Subject(s) - medicine , emtricitabine , placebo , bone mineral , randomized controlled trial , discontinuation , confidence interval , human immunodeficiency virus (hiv) , osteoporosis , viral load , immunology , antiretroviral therapy , alternative medicine , pathology
Daily preexposure prophylaxis (PrEP) with oral emtricitabine and tenofovir disoproxil fumarate (FTC/TDF) decreases the risk of human immunodeficiency virus (HIV) acquisition. Initiation of TDF decreases bone mineral density (BMD) in HIV-infected people. We report the effect of FTC/TDF on BMD in HIV-seronegative men who have sex with men and in transgender women.
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