Breast Milk Pharmacokinetics of Efavirenz and Breastfed Infants' Exposure in Genetically Defined Subgroups of Mother-Infant Pairs: An Observational Study | Zendy

Adeniyi Olagunju | Zendy; Oluseye O. Bolaji | Zendy; Alieu Amara | Zendy; Catriona Waitt | Zendy; Laura Else | Zendy; Ebunoluwa A. Adejuyigbe | Zendy; Marco Siccardi | Zendy; David Back | Zendy; Saye Khoo | Zendy; Andrew Owen | Zendy

Open Access

Breast Milk Pharmacokinetics of Efavirenz and Breastfed Infants' Exposure in Genetically Defined Subgroups of Mother-Infant Pairs: An Observational Study

Author(s) -

Adeniyi Olagunju,

Oluseye O. Bolaji,

Alieu Amara,

Catriona Waitt,

Laura Else,

Ebunoluwa A. Adejuyigbe,

Marco Siccardi,

David Back,

Saye Khoo,

Andrew Owen

Publication year - 2015

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/civ317

Subject(s) - efavirenz , medicine , breastfeeding , breast milk , pharmacokinetics , observational study , breast feeding , pediatrics , drug , physiology , human immunodeficiency virus (hiv) , pharmacology , antiretroviral therapy , virology , biology , viral load , biochemistry

The antiretroviral drug efavirenz is widely used during breastfeeding. Evaluating its safety requires an understanding of its breast milk pharmacokinetics, level of breastfed infants' exposure, and potential influence of polymorphisms in drug disposition genes.

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