Acute Gastrointestinal Graft-vs-Host Disease Is Associated With Increased Enteric Bacterial Bloodstream Infection Density in Pediatric Allogeneic Hematopoietic Cell Transplant Recipients | Zendy

Anya Levinson | Zendy; Kerice Pinkney | Zendy; Zhezhen Jin | Zendy; Monica Bhatia | Zendy; Andrew L. Kung | Zendy; Marc Foca | Zendy; Diane George | Zendy; James H. Garvin | Zendy; Jean Sosna | Zendy; Esra Karamehmet | Zendy; Chalitha Robinson | Zendy; Prakash Satwani | Zendy

Open Access

Acute Gastrointestinal Graft-vs-Host Disease Is Associated With Increased Enteric Bacterial Bloodstream Infection Density in Pediatric Allogeneic Hematopoietic Cell Transplant Recipients

Author(s) -

Anya Levinson,

Kerice Pinkney,

Zhezhen Jin,

Monica Bhatia,

Andrew L. Kung,

Marc Foca,

Diane George,

James H. Garvin,

Jean Sosna,

Esra Karamehmet,

Chalitha Robinson,

Prakash Satwani

Publication year - 2015

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/civ285

Subject(s) - medicine , incidence (geometry) , hazard ratio , graft versus host disease , hematopoietic stem cell transplantation , gastroenterology , disease , proportional hazards model , immunology , transplantation , sepsis , hematopoietic cell , haematopoiesis , confidence interval , stem cell , physics , biology , optics , genetics

Bacterial septicemia remains the leading cause of morbidity and mortality following allogeneic hematopoietic cell transplantation (AlloHCT). While murine studies have found acute gastrointestinal graft-vs-host disease (aG-GVHD) to be associated with increased incidence of enteric bacterial bloodstream infections (EB-BSI), this association has not been studied in humans. We hypothesized that in patients who developed aG-GVHD, the EB-BSI density after onset of aG-GVHD would be higher than before onset and higher than in patients without acute GVHD (aGVHD).

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