An Evaluation of a Novel Dual Treponemal/Nontreponemal Point-of-Care Test for Syphilis as a Tool to Distinguish Active From Past Treated Infection | Zendy

Louise Causer | Zendy; John Kaldor | Zendy; Damian P. Conway | Zendy; David Leslie | Zendy; Ian Denham | Zendy; Theo Karapanagiotidis | Zendy; Claire Ryan | Zendy; Handan Wand | Zendy; David A. Anderson | Zendy; Peter W. Robertson | Zendy; Anna McNulty | Zendy; Basil Donovan | Zendy; Christopher K. Fairley | Zendy; Rebecca Guy | Zendy

Open Access

An Evaluation of a Novel Dual Treponemal/Nontreponemal Point-of-Care Test for Syphilis as a Tool to Distinguish Active From Past Treated Infection

Author(s) -

Louise Causer,

John Kaldor,

Damian P. Conway,

David Leslie,

Ian Denham,

Theo Karapanagiotidis,

Claire Ryan,

Handan Wand,

David A. Anderson,

Peter W. Robertson,

Anna McNulty,

Basil Donovan,

Christopher K. Fairley,

Rebecca Guy

Publication year - 2015

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/civ243

Subject(s) - medicine , syphilis , rapid plasma reagin , concordance , point of care testing , confidence interval , point of care , serology , titer , syphilis serodiagnosis , immunology , antibody , pathology , treponema , human immunodeficiency virus (hiv)

Most syphilis point-of-care (POC) tests detect treponemal antibodies, which persist after successful treatment. Subsequent POC tests are positive, despite no active infection, and can lead to unnecessary treatment. We evaluated a new POC test, incorporating a nontreponemal component, to distinguish active from past infection.

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