Innate Susceptibility to Norovirus Infections Influenced by FUT2 Genotype in a United States Pediatric Population | Zendy

Rebecca L. Currier | Zendy; Daniel C. Payne | Zendy; Mary Allen Staat | Zendy; Rangaraj Selvarangan | Zendy; S. Hannah Shirley | Zendy; Natasha Halasa | Zendy; Julie A. Boom | Zendy; Janet A. Englund | Zendy; Peter G. Szilagyi | Zendy; Christopher J. Harrison | Zendy; Eileen J. Klein | Zendy; Geoffrey A. Weinberg | Zendy; Mary E. Wikswo | Zendy; Umesh D. Parashar | Zendy; Jan Vinjé | Zendy; Ardythe L. Morrow | Zendy

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Innate Susceptibility to Norovirus Infections Influenced by FUT2 Genotype in a United States Pediatric Population

Author(s) -

Rebecca L. Currier,

Daniel C. Payne,

Mary Allen Staat,

Rangaraj Selvarangan,

S. Hannah Shirley,

Natasha Halasa,

Julie A. Boom,

Janet A. Englund,

Peter G. Szilagyi,

Christopher J. Harrison,

Eileen J. Klein,

Geoffrey A. Weinberg,

Mary E. Wikswo,

Umesh D. Parashar,

Jan Vinjé,

Ardythe L. Morrow

Publication year - 2015

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/civ165

Subject(s) - norovirus , medicine , genotype , population , immunology , asymptomatic , virology , virus , environmental health , biology , gene , genetics

Norovirus is a leading cause of acute gastroenteritis (AGE). Noroviruses bind to gut histo-blood group antigens (HBGAs), but only 70%-80% of individuals have a functional copy of the FUT2 ("secretor") gene required for gut HBGA expression; these individuals are known as "secretors." Susceptibility to some noroviruses depends on FUT2 secretor status, but the population impact of this association is not established.

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