Antibiotic Dosing Discrepancies in the 2014 Skin and Soft Tissue Infections Guidelines

TO THE EDITOR—We read with interest the updated guidelines for the management of skin and soft tissue infections from the Infectious Diseases Society of America [1]. Their effort to expand on drug dosing is clear and appreciated. However, we would like to draw attention to a few dosing discrepancies. Table 3 [1] lists regimens for the treatment of intestinal or genitourinary tract infections following surgery. Ciprofloxacin is recommended in several instances at a dose of 400 mg IV every 12 hours or as the oral formulation at 750 mg PO every 12 hours. Based on drug bioavailability, an equivalent oral dose for 400 mg