Efficacy of HIV Postexposure Prophylaxis: Systematic Review and Meta-analysis of Nonhuman Primate Studies | Zendy

Cadi Irvine | Zendy; Kieren Egan | Zendy; Zara Shubber | Zendy; Koen K. A. Van Rompay | Zendy; Rachel Beanland | Zendy; Nathan Ford | Zendy

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Efficacy of HIV Postexposure Prophylaxis: Systematic Review and Meta-analysis of Nonhuman Primate Studies

Author(s) -

Cadi Irvine,

Kieren Egan,

Zara Shubber,

Koen K. A. Van Rompay,

Rachel Beanland,

Nathan Ford

Publication year - 2015

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/civ069

Subject(s) - medicine , nonhuman primate , meta analysis , primate , pre exposure prophylaxis , human immunodeficiency virus (hiv) , intensive care medicine , virology , immunology , biology , evolutionary biology , neuroscience , syphilis , men who have sex with men

The efficacy of antiretrovirals as postexposure prophylaxis (PEP) to prevent viral acquisition was demonstrated in nonhuman primate models of human immunodeficiency virus (HIV) in the early 1990s. To complement the evidence base for efficacy of HIV PEP in humans, we systematically reviewed the published data on PEP efficacy across animal studies.

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