Interleukin-18 Is Associated With Protection Against Rhinovirus-Induced Colds and Asthma Exacerbations | Zendy

David J. Jackson | Zendy; Nicholas Glanville | Zendy; MariaBelen TrujilloTorralbo | Zendy; Betty Shamji | Zendy; Jerico del-Rosario | Zendy; Patrick Mallia | Zendy; Matthew Edwards | Zendy; Ross P. Walton | Zendy; Michael R. Edwards | Zendy; Sebastian L. Johnston | Zendy

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Interleukin-18 Is Associated With Protection Against Rhinovirus-Induced Colds and Asthma Exacerbations

Author(s) -

David J. Jackson,

Nicholas Glanville,

MariaBelen TrujilloTorralbo,

Betty Shamji,

Jerico del-Rosario,

Patrick Mallia,

Matthew Edwards,

Ross P. Walton,

Michael R. Edwards,

Sebastian L. Johnston

Publication year - 2015

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/civ062

Subject(s) - rhinovirus , medicine , common cold , asthma , asthma exacerbations , immunology , respiratory system , interleukin , virus , cytokine

Rhinoviruses cause the common cold and exacerbations of asthma. Animal models of infection have identified a protective role for interleukin-18 (IL-18). Following experimental rhinovirus infection, we observed increased respiratory symptoms in healthy and asthmatic subjects with low nasal and bronchial IL-18 levels.

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