Validation of the Wild-type Influenza A Human Challenge Model H1N1pdMIST: An A(H1N1)pdm09 Dose-Finding Investigational New Drug Study | Zendy

Matthew J. Memoli | Zendy; Lindsay Czajkowski | Zendy; Susan Reed | Zendy; Rani Athota | Zendy; Tyler Bristol | Zendy; Kathleen Proudfoot | Zendy; Sarah Fargis | Zendy; Matthew K. Stein | Zendy; Rebecca L. Dunfee | Zendy; Pamela A. Shaw | Zendy; Richard T. Davey | Zendy; Jeffery K. Taubenberger | Zendy

Open Access

Validation of the Wild-type Influenza A Human Challenge Model H1N1pdMIST: An A(H1N1)pdm09 Dose-Finding Investigational New Drug Study

Author(s) -

Matthew J. Memoli,

Lindsay Czajkowski,

Susan Reed,

Rani Athota,

Tyler Bristol,

Kathleen Proudfoot,

Sarah Fargis,

Matthew K. Stein,

Rebecca L. Dunfee,

Pamela A. Shaw,

Richard T. Davey,

Jeffery K. Taubenberger

Publication year - 2014

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciu924

Subject(s) - medicine , viral shedding , virus , rhinorrhea , infectious dose , virology , titer , influenza a virus , drug , infectious disease (medical specialty) , disease , immunology , pharmacology

Healthy volunteer wild-type influenza challenge models offer a unique opportunity to evaluate multiple aspects of this important virus. Such studies have not been performed in the United States in more than a decade, limiting our capability to investigate this virus and develop countermeasures. We have completed the first ever wild-type influenza A challenge study under an Investigational New Drug application (IND). This dose-finding study will lead to further development of this model both for A(H1N1)pdm09 and other strains of influenza.

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