Application of the 2008 Definitions for Invasive Fungal Diseases to the Trial Comparing Voriconazole Versus Amphotericin B for Therapy of Invasive Aspergillosis: A Collaborative Study of the Mycoses Study Group (MSG 05) and the European Organization for Research and Treatment of Cancer Infectious Diseases Group | Zendy

Raoul Herbrecht | Zendy; Thomas F. Patterson | Zendy; Monica A. Slavin | Zendy; Oscar Marchetti | Zendy; Johan Maertens | Zendy; Elizabeth M. Johnson | Zendy; Haran T. Schlamm | Zendy; J. Peter Donnelly | Zendy; Peter G. Pappas | Zendy

Open Access

Application of the 2008 Definitions for Invasive Fungal Diseases to the Trial Comparing Voriconazole Versus Amphotericin B for Therapy of Invasive Aspergillosis: A Collaborative Study of the Mycoses Study Group (MSG 05) and the European Organization for Research and Treatment of Cancer Infectious Diseases Group

Author(s) -

Raoul Herbrecht,

Thomas F. Patterson,

Monica A. Slavin,

Oscar Marchetti,

Johan Maertens,

Elizabeth M. Johnson,

Haran T. Schlamm,

J. Peter Donnelly,

Peter G. Pappas

Publication year - 2014

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciu911

Subject(s) - voriconazole , aspergillosis , medicine , amphotericin b , antifungal , mycosis , randomized controlled trial , intensive care medicine , surgery , dermatology , immunology

Strict definition of invasive aspergillosis (IA) cases is required to allow precise conclusions about the efficacy of antifungal therapy. The Global Comparative Aspergillus Study (GCAS) compared voriconazole to amphotericin B (AmB) deoxycholate for the primary therapy of IA. Because predefined definitions used for this trial were substantially different from the consensus definitions proposed by the European Organization for Research and Treatment of Cancer/Mycoses Study Group in 2008, we recategorized the 379 episodes of the GCAS according to the later definitions.

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