Pertactin-Negative Bordetella pertussis Strains: Evidence for a Possible Selective Advantage
Author(s) -
Stacey W. Martin,
Lucia C. Pawloski,
Margaret M. Williams,
K. Weening,
Chas DeBolt,
Xuan Qin,
Laura Reynolds,
C. Kenyon,
G. P. Giambrone,
Kathy Kudish,
Lisa A. Miller,
David Selvage,
Arier Lee,
Tami H. Skoff,
Hajime Kamiya,
Pamela K. Cassiday,
M. Lucia Tondella,
Thomas A. Clark
Publication year - 2014
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciu788
Subject(s) - pertactin , bordetella pertussis , medicine , pertussis vaccine , immunology , immunization , bacteria , biology , pertussis toxin , genetics , antigen , g protein , receptor
A recent increase in Bordetella pertussis without the pertactin protein, an acellular vaccine immunogen, has been reported in the United States. Determining whether pertactin-deficient (PRN(-)) B. pertussis is evading vaccine-induced immunity or altering the severity of illness is needed.
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