Hepatitis C Core Antigen Testing: A Reliable, Quick, and Potentially Cost-effective Alternative to Hepatitis C Polymerase Chain Reaction in Diagnosing Acute Hepatitis C Virus Infection | Zendy

Fiona V Cresswell | Zendy; Martin Fisher | Zendy; D.J. Hughes | Zendy; Simon G. Shaw | Zendy; Gary Homer | Zendy; Mohammed O. Hassan-Ibrahim | Zendy

Open Access

Hepatitis C Core Antigen Testing: A Reliable, Quick, and Potentially Cost-effective Alternative to Hepatitis C Polymerase Chain Reaction in Diagnosing Acute Hepatitis C Virus Infection

Author(s) -

Fiona V Cresswell,

Martin Fisher,

D.J. Hughes,

Simon G. Shaw,

Gary Homer,

Mohammed O. Hassan-Ibrahim

Publication year - 2014

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciu782

Subject(s) - medicine , hepatitis c virus , virology , hepatitis c , polymerase chain reaction , immunology , viral disease , hepacivirus , flaviviridae , antigen , virus , biology , gene , biochemistry

Hepatitis C virus (HCV) is increasingly common among human immunodeficiency virus (HIV)-infected men who have sex with men. We evaluated the efficacy of HCV core antigen in diagnosing acute HCV in an HIV-infected cohort. Compared with HCV polymerase chain reaction, core antigen proved sensitive (100%) and specific (97.9%). As a quick, simple, and cost-effective test, it has considerable utility in screening for acute HCV.

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