The Association Between APOL1 Risk Alleles and Longitudinal Kidney Function Differs by HIV Viral Suppression Status
Author(s) -
Michelle M. Estrella,
Man Li,
Adrienne Tin,
Alison G. Abraham,
Michael G. Shlipak,
Sudhir Penugonda,
S. K. Hussain,
FJ Palella,
Steven M. Wolinsky,
Jeremy Martinson,
Rulan S. Parekh,
W.H. Linda Kao
Publication year - 2014
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciu765
Subject(s) - genotype , human immunodeficiency virus (hiv) , allele , longitudinal study , biology , renal function , virology , medicine , genetics , immunology , gene , pathology
Existing data suggest that human immunodeficiency virus (HIV)-infected African Americans carrying 2 copies of the APOL1 risk alleles have greater risk of kidney disease than noncarriers. We sought to determine whether HIV RNA suppression mitigates APOL1-related kidney function decline among African Americans enrolled in the Multicenter AIDS Cohort Study.
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