A Comparison of Lyme Disease Serologic Test Results From 4 Laboratories in Patients With Persistent Symptoms After Antibiotic Treatment | Zendy

Brian A. Fallon | Zendy; Martina Pavlicová | Zendy; Samantha Coffino | Zendy; Carl Brenner | Zendy

Open Access

A Comparison of Lyme Disease Serologic Test Results From 4 Laboratories in Patients With Persistent Symptoms After Antibiotic Treatment

Author(s) -

Brian A. Fallon,

Martina Pavlicová,

Samantha Coffino,

Carl Brenner

Publication year - 2014

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciu703

Subject(s) - medicine , serology , lyme disease , concordance , immunology , population , borrelia , immunoglobulin m , antibody , lyme , borrelia burgdorferi , immunoglobulin g , environmental health

As the incidence of Lyme disease (LD) has increased, a number of "Lyme specialty laboratories" have emerged, claiming singular expertise in LD testing. We investigated the degree of interlaboratory variability of several LD serologic tests-whole cell sonicate (WCS) enzyme-linked immunosorbent assay (ELISA), immunoglobulin M (IgM) and immunoglobulin G (IgG) Western blots (WBs), and an ELISA based on the conserved sixth region of variable major protein-like sequence expressed (C6)-that were performed at 1 university laboratory, 1 commercial laboratory, and 2 laboratories that specialize in LD testing.

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