Treating Progressive Multifocal Leukoencephalopathy With Interleukin 7 and Vaccination With JC Virus Capsid Protein VP1 | Zendy

Mireia Sospedra | Zendy; Sven Schippling | Zendy; Sara Yousef | Zendy; Ilijas Jelčić | Zendy; Sı́lvia Bofill-Mas | Zendy; Raquel Planas | Zendy; JanPatrick Stellmann | Zendy; Viktoria Demina | Zendy; Paola Cinque | Zendy; Robert L. Garcea | Zendy; Thérèse Croughs | Zendy; Rosina Gironés | Zendy; Roland Martinꝉ | Zendy

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Treating Progressive Multifocal Leukoencephalopathy With Interleukin 7 and Vaccination With JC Virus Capsid Protein VP1

Author(s) -

Mireia Sospedra,

Sven Schippling,

Sara Yousef,

Ilijas Jelčić,

Sı́lvia Bofill-Mas,

Raquel Planas,

JanPatrick Stellmann,

Viktoria Demina,

Paola Cinque,

Robert L. Garcea,

Thérèse Croughs,

Rosina Gironés,

Roland Martinꝉ

Publication year - 2014

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciu682

Subject(s) - progressive multifocal leukoencephalopathy , medicine , jc virus , capsid , virology , vaccination , adjuvant , virus , immunology , leukoencephalopathy , agonist , receptor , pathology , disease

Progressive multifocal leukoencephalopathy is a currently untreatable infection of the brain. Here, we demonstrate in 2 patients that treatment with interleukin 7, JC polyomavirus (JCV) capsid protein VP1, and a Toll-like receptor 7 agonist used as adjuvant, was well tolerated, and showed a very favorable safety profile and unexpected efficacy that warrant further investigation.

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