Open AccessInsufficient Fluconazole Exposure in Pediatric Cancer Patients and the Need for Therapeutic Drug Monitoring in Critically Ill Children
Author(s) -
Kim C. M. van der Elst,
Marieke Pereboom,
Edwin R. van den Heuvel,
Jos G.W. Kosterink,
Elisabeth H. Schölvinck,
JanWillem C. Alffenaar
Publication year - 2014
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciu657
Subject(s) - fluconazole , medicine , therapeutic drug monitoring , regimen , drug , pharmacokinetics , pharmacology , antifungal , dermatology
Fluconazole is recommended as first-line treatment in invasive candidiasis in children and infants. Although timely achievement of adequate exposure of fluconazole improves outcome, therapeutic drug monitoring is currently not recommended.
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