Neutrophil-Associated Central Nervous System Inflammation in Tuberculous Meningitis Immune Reconstitution Inflammatory Syndrome | Zendy

Suzaan Marais | Zendy; Katalin A. Wilkinson | Zendy; Maia Lesosky | Zendy; Anna K. Coussens | Zendy; Armin Deffur | Zendy; Dominique J. Pepper | Zendy; Charlotte Schutz | Zendy; Zahiera Ismail | Zendy; Graeme Meintjes | Zendy; Robert J. Wilkinson | Zendy

Open Access

Neutrophil-Associated Central Nervous System Inflammation in Tuberculous Meningitis Immune Reconstitution Inflammatory Syndrome

Author(s) -

Suzaan Marais,

Katalin A. Wilkinson,

Maia Lesosky,

Anna K. Coussens,

Armin Deffur,

Dominique J. Pepper,

Charlotte Schutz,

Zahiera Ismail,

Graeme Meintjes,

Robert J. Wilkinson

Publication year - 2014

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciu641

Subject(s) - immune reconstitution inflammatory syndrome , medicine , immunology , tuberculous meningitis , tuberculosis , iris (biosensor) , inflammation , immune system , cerebrospinal fluid , mycobacterium tuberculosis , chemokine , meningitis , disease , virus , pathology , viral load , antiretroviral therapy , surgery , computer security , computer science , biometrics

The immunopathogenesis of tuberculosis-associated immune reconstitution inflammatory syndrome (IRIS) remains incompletely understood, and we know of only 1 disease site-specific study of the underlying immunology; we recently showed that Mycobacterium tuberculosis culture positivity and increased neutrophils in the cerebrospinal fluid (CSF) of patients with tuberculous meningitis (TBM) are associated with TBM-IRIS. In this study we investigated inflammatory mediators at the disease site in patients with TBM-IRIS.

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