Intracellular Bacteria in the Pathogenesis of Escherichia coli Urinary Tract Infection in Children
Author(s) -
Luciana Robino,
Paola Scavone,
Lucía Araújo,
Gabriela Algorta,
Pablo Zunino,
Catalina Pírez,
Rafael Vignoli
Publication year - 2014
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciu634
Subject(s) - virulence , escherichia coli , microbiology and biotechnology , pathogenesis , urinary system , urothelium , bacteria , medicine , intracellular , multiplex polymerase chain reaction , odds ratio , biology , polymerase chain reaction , immunology , pathology , gene , genetics
Uropathogenic Escherichia coli (UPEC) is the most common agent of urinary tract infection (UTI). The classic model of pathogenesis proposes the ascent of UPEC by the urethra and external adherence to the urothelium. Recently, the ability of UPEC to invade urothelial cells and to form intracellular bacterial communities (IBCs) has been described.
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