Both Lewis and Secretor Status Mediate Susceptibility to Rotavirus Infections in a Rotavirus Genotype–Dependent Manner | Zendy

Johan Nordgren | Zendy; Sumit Sharma | Zendy; Filemón Bucardo | Zendy; Waqas Nasir | Zendy; Gökçe Günaydın | Zendy; Djénèba Ouermi | Zendy; Léon W. Nitièma | Zendy; Sylvia BeckerDreps | Zendy; Jacques Simporé | Zendy; Lennart Hammarström | Zendy; Göran Larson | Zendy; Lennart Svensson | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Both Lewis and Secretor Status Mediate Susceptibility to Rotavirus Infections in a Rotavirus Genotype–Dependent Manner

Author(s) -

Johan Nordgren,

Sumit Sharma,

Filemón Bucardo,

Waqas Nasir,

Gökçe Günaydın,

Djénèba Ouermi,

Léon W. Nitièma,

Sylvia BeckerDreps,

Jacques Simporé,

Lennart Hammarström,

Göran Larson,

Lennart Svensson

Publication year - 2014

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciu633

Subject(s) - rotavirus , genotype , medicine , immunology , rotavirus vaccine , population , antigen , virology , biology , genetics , virus , gene , environmental health

The live oral rotavirus (RV) vaccines have shown a reduced efficacy in Africa. Recent in vitro studies have shown binding of the RV surface protein (VP4) to histo-blood group antigens (HBGAs) in an RV genotype-dependent manner, suggesting them to be putative receptors for RV. The diversity of HBGA phenotypes in different ethnic populations, combined with prevalence/absence of specific RV genotypes, led us to hypothesize whether the genetic variations in HBGAs in a population limit susceptibility to certain RV genotypes, plausibly leading to reduced vaccine efficacy.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research