Vancomycin Exposure in Patients With Methicillin-Resistant Staphylococcus aureus Bloodstream Infections: How Much Is Enough? | Zendy

Thomas P. Lodise | Zendy; George L. Drusano | Zendy; Evan J. Zasowski | Zendy; Amanda Dihmess | Zendy; Victoria Lazariu | Zendy; Leon E. Cosler | Zendy; LouiseAnne McNutt | Zendy

Open Access

Vancomycin Exposure in Patients With Methicillin-Resistant Staphylococcus aureus Bloodstream Infections: How Much Is Enough?

Author(s) -

Thomas P. Lodise,

George L. Drusano,

Evan J. Zasowski,

Amanda Dihmess,

Victoria Lazariu,

Leon E. Cosler,

LouiseAnne McNutt

Publication year - 2014

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciu398

Subject(s) - medicine , vancomycin , staphylococcus aureus , bloodstream infection , minimum inhibitory concentration , methicillin resistant staphylococcus aureus , microbiology and biotechnology , micrococcaceae , staphylococcal infections , bacteremia , antibiotics , antibacterial agent , intensive care medicine , bacteria , biology , genetics

Contemporary vancomycin dosing schemes are designed to achieve an area under the curve (AUC) to minimum inhibitory concentration (MIC) ratio of ≥400. However, scant clinical data exist to support this target and available data relied on pharmacokinetic formulas based on daily vancomycin dose and estimated renal function (demographic pharmacokinetic model) to estimate AUCs.

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