English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

TO THE EDITOR—The recent publication by Price et al [1] uses novel methods to illustrate the complex dynamics involved in nosocomial transmission of Staphylococcus aureus through the use of wholegenome sequencing. However, the claim that patient-to-patient transmission is a rare occurrence is not well justified by the presented data. The authors report 7 of 37 (18.7%) patient-to patient transmission events based on whole-genome sequencing of isolates with available spa typing results. Our calculated confidence intervals for these proportions range from 6.3% to 31.5%. Furthermore, if only methicillinresistant S. aureus transmission events in isolates with available spa types are analyzed, the proportion increases to 5 of 14 (35.7%), with confidence intervals of 10.6%–60.8%. These numbers are more consistent with existing data on rates of horizontal transmission of S. aureus [2]. Although the study clearly shows the limitations of conventional methods of transmission assessment, the data are far from conclusive in exonerating patient-topatient transmission as a major source of in-hospital S. aureus acquisition.

clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)

Data on Whole-Genome Sequencing Are Insufficient to Rule Out Patient-to-Patient Transmission as a Significant Source of Staphylococcus aureus Acquisition in an Intensive Care Unit