Dependence on the CCR5 Coreceptor for Viral Replication Explains the Lack of Rebound of CXCR4-Predicted HIV Variants in the Berlin Patient | Zendy

Jori Symons | Zendy; Linos Vandekerckhove | Zendy; Gero Hütter | Zendy; Annemarie M. J. Wensing | Zendy; Petra M. van Ham | Zendy; Steven G. Deeks | Zendy; Monique Nijhuis | Zendy

Open Access

Dependence on the CCR5 Coreceptor for Viral Replication Explains the Lack of Rebound of CXCR4-Predicted HIV Variants in the Berlin Patient

Author(s) -

Jori Symons,

Linos Vandekerckhove,

Gero Hütter,

Annemarie M. J. Wensing,

Petra M. van Ham,

Steven G. Deeks,

Monique Nijhuis

Publication year - 2014

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciu284

Subject(s) - cxcr4 , medicine , human immunodeficiency virus (hiv) , virology , transplantation , viral replication , immunology , virus , chemokine , immune system

The "Berlin patient" is the first patient cured of HIV-1 infection after allogeneic transplantation with nonfunctional CCR5 coreceptor stem cells. We demonstrate that CXCR4-predicted minority viruses present prior to transplantation were unable to rebound after transplantation due to their dependence on CCR5 for replication and high genetic barrier toward CXCR4 usage.

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