Mannose-Binding Lectin Gene, MBL2, Polymorphisms Are Not Associated With Susceptibility to Invasive Pneumococcal Disease in Children | Zendy

Lene Fogt Lundbo | Zendy; Zitta Barrella Harboe | Zendy; Louise Nygaard Clausen | Zendy; Mads V. Hollegaard | Zendy; Henrik Toft Sørensen | Zendy; D. M. Hougaard | Zendy; Helle Bossen Konradsen | Zendy; Mette Nørgaard | Zendy; Thomas Benfield | Zendy

Open Access

Mannose-Binding Lectin Gene, MBL2, Polymorphisms Are Not Associated With Susceptibility to Invasive Pneumococcal Disease in Children

Author(s) -

Lene Fogt Lundbo,

Zitta Barrella Harboe,

Louise Nygaard Clausen,

Mads V. Hollegaard,

Henrik Toft Sørensen,

D. M. Hougaard,

Helle Bossen Konradsen,

Mette Nørgaard,

Thomas Benfield

Publication year - 2014

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciu276

Subject(s) - medicine , mannan binding lectin , odds ratio , streptococcus pneumoniae , immunology , meningitis , bacteremia , serotype , pediatrics , genetics , antibiotics , biology , lectin

Most children are transiently colonized with Streptococcus pneumoniae, but very few develop invasive pneumococcal disease (IPD). Host genetic variation of innate immunity may predispose to IPD. We investigated the effect of genetic variation in the mannose-binding lectin gene, MBL2, on susceptibility and disease severity of IPD in previously healthy children aged <5 years.

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