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Invasive Pneumococcal Disease in Children Can Reveal a Primary Immunodeficiency
Author(s) -
Jean Gaschignard,
Corinne Lévy,
Maya Chrabieh,
Bertrand Boisson,
C. Bost-Bru,
Stéphane Dauger,
François Dubos,
Philippe Durand,
J. Gaudelus,
D Gendrel,
Christèle GrasLe Guen,
E. Grimprel,
G. Guyon,
C. Jeudy,
Éric Jeziorski,
Francis Leclerc,
Pierre-Louis Léger,
Fabrice Lesage,
Mathie Lorrot,
Isabelle Pellier,
Didier Pinquier,
Loïc de Pontual,
P. Sachs,
Caroline Thomas,
Pierre Tissières,
Frédéric V. Valla,
P Desprez,
Véronique FrémeauxBacchi,
Emmanuelle Varon,
Xavier Bossuyt,
Robert Cohen,
Laurent Abel,
JeanLaurent Casanova,
Anne Puel,
Capucine Pïcard
Publication year - 2014
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciu274
Subject(s) - medicine , meningitis , pediatrics , primary immunodeficiency , immunology , streptococcus pneumoniae , mastoiditis , asplenia , disease , otitis , surgery , antibiotics , spleen , microbiology and biotechnology , biology
About 10% of pediatric patients with invasive pneumococcal disease (IPD) die from the disease. Some primary immunodeficiencies (PIDs) are known to confer predisposition to IPD. However, a systematic search for these PIDs has never been carried out in children presenting with IPD.

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