Topical Application of Imiquimod as a Treatment for Chromoblastomycosis | Zendy

Maria Glória Teixeira Sousa | Zendy; Walter Belda | Zendy; Ricardo Spina | Zendy; Priscila Ramos Lota | Zendy; Neusa Sakai Valente | Zendy; Gordon D. Brown | Zendy; Paulo Ricardo Criado | Zendy; Gil Benard | Zendy

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Topical Application of Imiquimod as a Treatment for Chromoblastomycosis

Author(s) -

Maria Glória Teixeira Sousa,

Walter Belda,

Ricardo Spina,

Priscila Ramos Lota,

Neusa Sakai Valente,

Gordon D. Brown,

Paulo Ricardo Criado,

Gil Benard

Publication year - 2014

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciu168

Subject(s) - chromoblastomycosis , imiquimod , medicine , dermatology , mycosis , antifungal , chemotherapy , surgery

Chromoblastomycosis is a subcutaneous mycosis that remains a therapeutic challenge, with no standard treatment and high rates of relapse. On the basis of our recent discoveries in mouse models, we tested the efficacy of topical applications of imiquimod to treat patients afflicted with this chronic fungal infection. We report results of treatment for the first 4 recipients of topical imiquimod, all of whom displayed a marked improvement of their lesions, both with and without concurrent oral antifungal therapy.

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