Is the Interleukin 8 Promoter Polymorphism rs4073/-251T >A Associated With Clostridium difficile Infection? | Zendy

Fábio Miyajima | Zendy; Andrew Swale | Zendy; J. E. Zhang | Zendy; Ana Alfirevic | Zendy; Margaret Little | Zendy; Nicholas J. Beeching | Zendy; G Smith | Zendy; Ruwanthi KolamunnageDona | Zendy; Munir Pirmohamed | Zendy

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Is the Interleukin 8 Promoter Polymorphism rs4073/-251T >A Associated With Clostridium difficile Infection?

Author(s) -

Fábio Miyajima,

Andrew Swale,

J. E. Zhang,

Ana Alfirevic,

Margaret Little,

Nicholas J. Beeching,

G Smith,

Ruwanthi KolamunnageDona,

Munir Pirmohamed

Publication year - 2014

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciu152

Subject(s) - clostridium difficile , medicine , single nucleotide polymorphism , microbiology and biotechnology , clostridiaceae , gene , genotype , immunology , virology , genetics , biology , antibiotics , toxin

The interleukin 8 gene single-nucleotide polymorphism rs4073/-251T >A predisposes to Clostridium difficile infection (CDI), but this association has not been independently validated. In this study, we were unable to replicate this association in either a white cohort or by meta-analysis, suggesting that rs4073/-251T >A is unlikely to constitute a major risk factor for CDI.

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