Increased HIV-1 Activity in Anal High-Grade Squamous Intraepithelial Lesions Compared With Unaffected Anal Mucosa in Men Who Have Sex With Men | Zendy

Georgios Pollakis | Zendy; Olivier Richel | Zendy; J. D. Vis | Zendy; Jan M. Prins | Zendy; William A. Paxton | Zendy; Henry J.C. de Vries | Zendy

Open Access

Increased HIV-1 Activity in Anal High-Grade Squamous Intraepithelial Lesions Compared With Unaffected Anal Mucosa in Men Who Have Sex With Men

Author(s) -

Georgios Pollakis,

Olivier Richel,

J. D. Vis,

Jan M. Prins,

William A. Paxton,

Henry J.C. de Vries

Publication year - 2014

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciu133

Subject(s) - medicine , men who have sex with men , human immunodeficiency virus (hiv) , anal sex , anal canal , anal cancer , gynecology , gastroenterology , immunology , rectum , syphilis

We studied 3 patients with focal intra-anal tissue high-grade squamous intraepithelial lesions (HSILs). All had increased human immunodeficiency virus type 1 (HIV-1) RNA and DNA in lesions compared with that in healthy mucosa. HIV-1 RNA and HIV-1 episomal DNA were indicative of ongoing viral replication, more so in anal HSILs.

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